Association between platelet glycoprotein Ibα genotype and ischemic cerebrovascular disease

Akira Sonoda, Mitsuru Murata, Daisuke Ito, Norio Tanahashi, Atsumi Ohta, Yoko Tada, Eiko Takeshita, Tadashi Yoshida, Ikuo Saito, Masatoshi Yamamoto, Yasuo Ikeda, Yasuo Fukuuchi, Kiyoaki Watanabe

研究成果: Article査読

77 被引用数 (Scopus)

抄録

Background and Purpose - Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD. Methods - Two hundred patients with ischemic CVD, as confirmed by brain CT and/or MRI, and 317 age- and sex-matched control subjects without clinical evidence of CVD or cardiovascular disease were analyzed for their genotype frequencies of the 145Thr/Met dimorphism of the α-chain of GPIb (GPIbα). Results - Genotypes with 145Met (T/M and M/M) were more frequently found in the CVD patients (26.5%) than in control subjects (14.2%, P=0.0005). The genotype effect was more obvious in those <60 years of age or without acquired cardiovascular risk factors. The odds ratio for nonsmoking women <60 years of age was 10.6 (95% confidence intervals, 2.2 to 51.7). Although the number of patients studied was small (n=24), transient ischemic attack showed the highest odds ratio (4.3, P=0.0004), followed by lacunar infarction (OR=2.2, P=0.0024) and atherothrombotic infarction (OR=1.5, P=0.3143). Logistic regression analysis revealed that the presence of Met-allele was independently associated with CVD. Conclusions - Our study suggests that the platelet GPIbα genotype is a genetic risk factor for ischemic CVD.

本文言語English
ページ(範囲)493-497
ページ数5
ジャーナルStroke
31
2
DOI
出版ステータスPublished - 2000 2月

ASJC Scopus subject areas

  • 臨床神経学
  • 循環器および心血管医学
  • 高度および特殊看護

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