Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

Shinji Tamaki; Yasuyuki Nakamura; Yasuharu Tabara; Tomonori Okamura; Hideyuki Kanda; Yoshikuni Kita; Takashi Kadowaki; Yasuyuki Tsujita; Tanvir Chowdhury Turin; Minoru Horie; Tetsuro Miki; Hirotsugu Ueshima

doi:10.1016/j.ijcard.2008.04.079

Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

Shinji Tamaki, Yasuyuki Nakamura, Yasuharu Tabara, Tomonori Okamura, Hideyuki Kanda, Yoshikuni Kita, Takashi Kadowaki, Yasuyuki Tsujita, Tanvir Chowdhury Turin, Minoru Horie, Tetsuro Miki, Hirotsugu Ueshima

研究成果: Article › 査読

1 被引用数 (Scopus)

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We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

本文言語	English
ページ（範囲）	354-355
ページ数	2
ジャーナル	International Journal of Cardiology
巻	136
号	3
DOI	https://doi.org/10.1016/j.ijcard.2008.04.079
出版ステータス	Published - 2009 8月 21
外部発表	はい

ASJC Scopus subject areas

循環器および心血管医学

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10.1016/j.ijcard.2008.04.079

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引用スタイル

Tamaki, S., Nakamura, Y., Tabara, Y., Okamura, T., Kanda, H., Kita, Y., Kadowaki, T., Tsujita, Y., Chowdhury Turin, T., Horie, M., Miki, T., & Ueshima, H. (2009). Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). International Journal of Cardiology, 136(3), 354-355. https://doi.org/10.1016/j.ijcard.2008.04.079

Tamaki, S, Nakamura, Y, Tabara, Y, Okamura, T, Kanda, H, Kita, Y, Kadowaki, T, Tsujita, Y, Chowdhury Turin, T, Horie, M, Miki, T & Ueshima, H 2009, 'Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)', International Journal of Cardiology, vol. 136, no. 3, pp. 354-355. https://doi.org/10.1016/j.ijcard.2008.04.079

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abstract = "We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).",

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AU - Tamaki, Shinji

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AU - Tabara, Yasuharu

AU - Okamura, Tomonori

AU - Kanda, Hideyuki

AU - Kita, Yoshikuni

AU - Kadowaki, Takashi

AU - Tsujita, Yasuyuki

AU - Chowdhury Turin, Tanvir

AU - Horie, Minoru

AU - Miki, Tetsuro

AU - Ueshima, Hirotsugu

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N2 - We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

AB - We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

KW - A1166C polymorphism

KW - AGTR1

KW - Cardiovascular events

KW - Prospective cohort study

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Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

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