Association between pulse wave velocity and coronary artery calcification in Japanese men the shiga epidemiological study of subclinical atherosclerosis (SESSA

SESSA Research group

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Aim: Pulse wave velocity (PWV is a simple and valid clinical method for assessing arterial stiffness. Coronary artery calcification (CAC is an intermediate stage in the process leading to overt cardiovascular disease (CVD and an established determinant of coro nary artery disease. This study aimed to examine the association between PWV and CAC in a population-based sample of Japanese men. Methods: This is a cross-sectional study of 986 randomly selected men aged 40-79 years from Shiga, Japan. CVD-free participants were examined from 2006 to 2008. Brachial-ankle PWV (baPWV was measured using an automatic waveform analyzer. CAC was assessed using computed tomography. Agatston scores ≥ 10 were defined as the presence of CAC. Results: Prevalence of CAC progressively increased with rising levels of baPWV: 20.6%, 41.7%, 56.3%, and 66.7% across baPWV quartiles <1378, 1378-1563, 1564-1849, and >1849 cm/s (P< 0.001 for trend. Associations remained significant after adjusting for age and other factors, including body mass index, systolic blood pressure, pulse rate, total and high-density lipoprotein cholesterol, hemoglobin A1c, drinking, smoking and exercise status, and the use of medication to treat hypertension, dyslipidemia and diabetes (P= 0.042 for trend. The optimal cutoff level of baPWV to detect CAC was 1612 cm/s using receiver operating characteristic curve analysis. Conclusions: Arterial stiffness as defined by an elevated baPWV is associated with an increased prevalence of CAC in a general population-based setting among Japanese men.

本文言語English
ページ(範囲)1266-1277
ページ数12
ジャーナルJournal of atherosclerosis and thrombosis
22
12
DOI
出版ステータスPublished - 2015 12月 1
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 循環器および心血管医学
  • 生化学、医学

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