Association between white matter hyperintensity and lacunar infarction on MRI and subitem scores of the Japanese version of mini-mental state examination for testing cognitive decline: The Ohasama study

Eman M. Elnimr, Takeo Kondo, Yoshimi Suzukamo, Michihiro Satoh, Yutaka Oouchida, Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Mikio Hirano, Aya Hosokawa, Toru Hosokawa, Yutaka Imai, Shin Ichi Izumi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

We assessed whether subitem scores on the Mini-Mental State Examination (MMSE) associated independently with cerebral white matter hyperintensity (WMH) and lacunar infarction (LI). Magnetic resonance imaging (MRI) and neuropsychological evaluation (MMSE) were performed in 1008 elderly individuals from the Ohasama Study (348 men, 660 women [65.5%]; age 68.0 ± 6.0 [mean ± SD] years; MMSE score, 26.5 ± 2.9). The relationships between MRI findings and MMSE subitem scores were analyzed by logistic regression. Significant associations were observed between the MMSE subitems "Orientation to place" and WMH, and "Copy a figure" and LI. Pathological changes were detected by brain MRI associated with a decrease in cognitive function in healthy elderly individuals.

本文言語English
ページ(範囲)541-547
ページ数7
ジャーナルClinical and Experimental Hypertension
34
8
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 生理学

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