Association of mild hyperhomocysteinemia with aortic calcification in hypercholesterolemic patients.

N. Hirose, Yasumichi Arai, T. Ishii, M. Tushima, J. Li

研究成果: Article

13 引用 (Scopus)

抄録

Homocysteine is considered to be an independent risk factor for atherosclerosis. Experimental animal models of hyperhomocysteinemia show aortic calcification, suggesting that this disorder is associated with aortic calcification in humans. A total of 28 patients with hyperlipidemia were enrolled into this study. The degree of aortic calcification at the level of the bifurcation and 1 cm proximal to the bifurcation was assessed by computed tomography of the aorta and the association between calcification of the aorta and the plasma level of homocysteine was then analyzed. The mean plasma homocysteine level in 28 patients was 8.7 microM. They were divided into 2 groups, high homocysteine level group (HHL; homocysteine level >8.7 microM) and low homocysteine level group (LHL; homocysteine level < = 8.7 microM). The degree of aortic calcification at the level of the bifurcation differed significantly between the two groups (19.1% vs. 10.5%; p < 0.01). We found that mild hyperhomocysteinemia was associated with aortic calcification, which suggests that interventions to reduce the plasma level of homocysteine may also reduce the severity of aortic calcification.

元の言語English
ページ(範囲)91-94
ページ数4
ジャーナルJournal of Atherosclerosis and Thrombosis
8
発行部数3
出版物ステータスPublished - 2001

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Hyperhomocysteinemia
Homocysteine
Plasmas
Aorta
Hyperlipidemias
Tomography
Atherosclerosis
Animals
Animal Models

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

これを引用

Association of mild hyperhomocysteinemia with aortic calcification in hypercholesterolemic patients. / Hirose, N.; Arai, Yasumichi; Ishii, T.; Tushima, M.; Li, J.

:: Journal of Atherosclerosis and Thrombosis, 巻 8, 番号 3, 2001, p. 91-94.

研究成果: Article

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AU - Arai, Yasumichi

AU - Ishii, T.

AU - Tushima, M.

AU - Li, J.

PY - 2001

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