Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with schizophrenia in the Japanese population

Shinsuke Washizuka, Mizue Kametani, Tsukasa Sasaki, Mamoru Tochigi, Tadashi Umekage, Kazuhisa Kohda, Tadafumi Kato

研究成果: Article査読

47 被引用数 (Scopus)

抄録

Schizophrenia and bipolar disorder share common genetic background. Several loci such as 18p11, 13q32, and 22q11-13 were commonly linked with these diseases. Since mitochondrial dysfunction has been suggested in both of these disorders, NDUFV2 at 18p11, encoding a subunit of the complex I, NADH ubiquinone oxidoreductase, is a candidate gene for these diseases. We previously reported that single nucleotide polymorphisms (SNPs) in the upstream region of NDUFV2 were associated with bipolar disorder in Japanese. The association of haplotype consisting of two SNPs, -3542G > A and -602G > A, with bipolar disorder was also seen both in Japanese and the National Institute of Mental Health Pedigrees trios. In this study, 2 polymorphisms, -3542G > A and -602G > A, were investigated in 229 schizophrenic patients as compared with controls. Individual genotypes were not associated with schizophrenia. However, the haplotype consisting of these two SNPs were significantly associated with schizophrenia. These results suggested that inter-individual variation of the genomic sequence of the promoter region of NDUFV2 might be a genetic risk factor common to bipolar disorder and schizophrenia.

本文言語English
ページ(範囲)301-304
ページ数4
ジャーナルAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
141 B
3
DOI
出版ステータスPublished - 2006 4月 5

ASJC Scopus subject areas

  • 遺伝学(臨床)
  • 精神医学および精神衛生
  • 細胞および分子神経科学

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