TY - JOUR
T1 - Association of pancreatic fatty infiltration with pancreatic ductal adenocarcinoma
AU - Hori, Mika
AU - Takahashi, Mami
AU - Hiraoka, Nobuyoshi
AU - Yamaji, Taiki
AU - Mutoh, Michihiro
AU - Ishigamori, Rikako
AU - Furuta, Koh
AU - Okusaka, Takuji
AU - Shimada, Kazuaki
AU - Kosuge, Tomoo
AU - Kanai, Yae
AU - Nakagama, Hitoshi
N1 - Funding Information:
present study was approved by the Ethics Review Committee of the National Cancer Center (2010-088). The materials are from patients who had given general consent for the research use of their leftover samples, and all clinical investigations were conducted in accordance with the principles of the Declaration of Helsinki.
Funding Information:
Acknowledgments. The National Cancer Center Biobank is supported by the National Cancer Center Research and Development Fund, Japan.
Funding Information:
CONFLICT OF INTEREST Guarantor of the article: Hitoshi Nakagama, MD, DMSc. Specific author contributions: Mika Hori contributed to the design of the study, acquisition, analysis and interpretation of data, writing and drafting of the manuscript; Mami Takahashi contributed to the conception of the study, development of methodology and data analysis and revision of the manuscript; Nobuyoshi Hiraoka contributed to the histopathological analysis and revision of the manuscript; Taiki Yamaji contributed to the statistical analysis and revision of the manuscript; Michihiro Mutoh contributed to data analysis and revision of the manuscript; Rikako Ishigamori contributed to the histopathological analysis; Koh Furuta contributed to material supports in human serum analysis; Takuji Okusaka contributed to the clinical revision of the manuscript; Kazuaki Shimada contributed to the clinical revision of the manuscript; Tomoo Kosuge contributed to the clinical revision of the manuscript; Yae Kanai contributed to the histopathological analysis; Hitoshi Nakagama contributed to study supervision and revision of the manuscript. Financial support: This work was supported by: Grants-in-Aid for Cancer Research from the Ministry of Health, Labour, and Welfare of Japan and Management Expenses Grants from the Government to the National Cancer Center (21–2–1, 23-A-4); a grant of the Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor, and Welfare of Japan; a grant of the Research Grant of the Princess Takamatsu Cancer Research Fund; Grants-in-Aid from the Foundation for Promotion of Cancer Research and the Pancreas Research Foundation of Japan. M. Hori was an Awardee of Research Resident Fellowships from the Foundation for Promotion of Cancer Research (Japan) and from the Third-Term Comprehensive 10-Year Strategy for Cancer Control during the course of the present research. Potential competing interests: None.
PY - 2014/3/13
Y1 - 2014/3/13
N2 - OBJECTIVES:Fatty infiltration (FI) in the pancreas is positively correlated with high body mass index (BMI) or obesity, and the prevalence of diabetes mellitus (DM), which are well-known risk factors of pancreatic cancer. However, the association of FI in the pancreas with pancreatic cancer is unclear. Recently, we have shown that Syrian golden hamsters feature FI of the pancreas, the severity of which increases along with the progression of carcinogenesis induced by a chemical carcinogen. To translate the results to a clinical setting, we investigated whether FI in the pancreas is associated with pancreatic cancer in a series of patients who had undergone pancreatoduodenectomy.METHODS:In the series, we identified 102 cases with pancreatic ductal adenocarcinoma (PDAC) and 85 controls with cancers except for PDAC. The degree of FI was evaluated histopathologically from the area occupied by adipocytes in pancreas sections, and was compared between the cases and controls.RESULTS:The degree of FI in the pancreas was significantly higher in cases than in controls (median 26 vs. 15%, P<0.001) and positively associated with PDAC, even after adjustment for BMI, prevalence of DM and other confounding factors (odds ratio (OR), 6.1; P<0.001). BMI was identified as the most significantly associated factor with FI in the pancreas.CONCLUSIONS: There is a positive correlation between FI in the pancreas and pancreatic cancer.
AB - OBJECTIVES:Fatty infiltration (FI) in the pancreas is positively correlated with high body mass index (BMI) or obesity, and the prevalence of diabetes mellitus (DM), which are well-known risk factors of pancreatic cancer. However, the association of FI in the pancreas with pancreatic cancer is unclear. Recently, we have shown that Syrian golden hamsters feature FI of the pancreas, the severity of which increases along with the progression of carcinogenesis induced by a chemical carcinogen. To translate the results to a clinical setting, we investigated whether FI in the pancreas is associated with pancreatic cancer in a series of patients who had undergone pancreatoduodenectomy.METHODS:In the series, we identified 102 cases with pancreatic ductal adenocarcinoma (PDAC) and 85 controls with cancers except for PDAC. The degree of FI was evaluated histopathologically from the area occupied by adipocytes in pancreas sections, and was compared between the cases and controls.RESULTS:The degree of FI in the pancreas was significantly higher in cases than in controls (median 26 vs. 15%, P<0.001) and positively associated with PDAC, even after adjustment for BMI, prevalence of DM and other confounding factors (odds ratio (OR), 6.1; P<0.001). BMI was identified as the most significantly associated factor with FI in the pancreas.CONCLUSIONS: There is a positive correlation between FI in the pancreas and pancreatic cancer.
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U2 - 10.1038/ctg.2014.5
DO - 10.1038/ctg.2014.5
M3 - Article
AN - SCOPUS:84896288360
SN - 2155-384X
VL - 5
JO - Clinical and Translational Gastroenterology
JF - Clinical and Translational Gastroenterology
M1 - e53
ER -
