Association of (Pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery

Tomoko Takemitsu, Atsuhiro Ichihara, Yuki Kaneshiro, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Norimasa Yamashita, Hiroshi Itoh

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Background/Aims: A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery. Methods: In 141 kidney failure patients, the mRNA was harvested from arterial fragments obtained during surgery constructing an arteriovenous access for hemodialysis therapy, and expression levels of (pro)renin receptor and other components of the renin-angiotensin system were determined. Results: Arterial (pro)renin receptor expression was similar in diabetic and non-diabetic patients, although plasma prorenin levels were significantly higher in the diabetic patients than in the non-diabetic patients. The arterial (pro)renin receptor mRNA levels of the hypertensive patients, who had not been treated with either angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers, were significantly lower than those of the patients who had been treated with either drug. Multiple regression analyses showed a significant association with a large coefficient between the arterial mRNA level of the (pro)renin receptor and the arterial mRNA level of ACE; this significant association disappeared in patients who had been treated with either drug. Conclusion: (Pro)renin receptor may contribute to the generation of arterial angiotensin II in kidney failure patients.

本文言語English
ページ(範囲)361-370
ページ数10
ジャーナルAmerican Journal of Nephrology
30
4
DOI
出版ステータスPublished - 2009 10 1

ASJC Scopus subject areas

  • 腎臓病学

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