Association of structural polymorphism of the dopamine D2 receptor gene and alcoholism

Susumu Higuchi, Taro Muramatsu, Masanobu Murayama, Motoi Hayashida

研究成果: Article査読

47 被引用数 (Scopus)

抄録

To examine the possible association between three recently identified structural polymorphisms of the dopamine D2 receptor (DRD2) gene and alcoholism, we compared allele frequencies of these polymorphisms in 280 Japanese alcoholics and 289 normal controls. The results revealed that only one of three variants identified in white individuals existed in the alcoholic and control Japanese. The frequency of the Cys311 variant allele was significantly higher in alcoholics (.063) than in controls (.029). All of the subjects with the variant allele were heterozygous Ser311/Cys311. Patients with Cys311 allele had less severe symptoms of alcoholism than did those with homozygous Ser311, especially symptoms related to loss of control over drinking. The coprevalence of other psychiatric disorders including schizophrenia did not differ between the two patient groups. These results suggest that the D2/Cys311 variant is associated with some type of alcoholism in Japanese.

本文言語English
ページ(範囲)1199-1205
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
204
3
DOI
出版ステータスPublished - 1994 11 14
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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