Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

K. Nishimoto, Y. Kochi, K. Ikari, K. Yamamoto, A. Suzuki, K. Shimane, Y. Nakamura, K. Yano, N. Iikuni, S. Tsukahara, N. Kamatani, H. Okamoto, H. Kaneko, Y. Kawaguchi, M. Hara, Y. Toyama, T. Horiuchi, K. Tao, D. Yasutomo, N. YasuiH. Inoue, M. Itakura, H. Yamanaka, S. Momohara

研究成果: Article

29 引用 (Scopus)

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Objective: The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in Japanese populations. Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed. Methods: A multicentre association study consisting of 4 RA case-control series (4397 cases and 2857 controls) and 3 SLE case-control series (591 cases and 2199 shared controls) was conducted. Genotyping was performed using TaqMan genotyping assay for two single nucleotide polymorphisms (SNPs) that showed the best evidence of association in the previous Caucasian studies. Quantifications of TRAF1 and C5 expression were performed with TaqMan expression assay. Results: Significant differences in allele frequency for both SNPs were observed between RA and control subjects (combined odds ratio =1.09), while no significant difference was detected between patients with SLE and controls. Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies. A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetatestimulated lymphoblastoid cell lines (p=0.04). Conclusion: Association of TRAF1-C5 locus with RA susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for SLE. Significant positive effect of genotype on the expression of TRAF1 might support the genetic association between TRAF1 and RA.

元の言語English
ページ(範囲)368-373
ページ数6
ジャーナルAnnals of the Rheumatic Diseases
69
発行部数2
DOI
出版物ステータスPublished - 2010 2

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TNF Receptor-Associated Factor 1
Polymorphism
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Association reactions
Single Nucleotide Polymorphism
Assays
Nucleotides
Alleles
Genotype
Myristic Acid
Gene Frequency
Gene expression
Population
Multicenter Studies
Odds Ratio
Cells
Gene Expression
Cell Line

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

これを引用

Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. / Nishimoto, K.; Kochi, Y.; Ikari, K.; Yamamoto, K.; Suzuki, A.; Shimane, K.; Nakamura, Y.; Yano, K.; Iikuni, N.; Tsukahara, S.; Kamatani, N.; Okamoto, H.; Kaneko, H.; Kawaguchi, Y.; Hara, M.; Toyama, Y.; Horiuchi, T.; Tao, K.; Yasutomo, D.; Yasui, N.; Inoue, H.; Itakura, M.; Yamanaka, H.; Momohara, S.

:: Annals of the Rheumatic Diseases, 巻 69, 番号 2, 02.2010, p. 368-373.

研究成果: Article

Nishimoto, K, Kochi, Y, Ikari, K, Yamamoto, K, Suzuki, A, Shimane, K, Nakamura, Y, Yano, K, Iikuni, N, Tsukahara, S, Kamatani, N, Okamoto, H, Kaneko, H, Kawaguchi, Y, Hara, M, Toyama, Y, Horiuchi, T, Tao, K, Yasutomo, D, Yasui, N, Inoue, H, Itakura, M, Yamanaka, H & Momohara, S 2010, 'Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese', Annals of the Rheumatic Diseases, 巻. 69, 番号 2, pp. 368-373. https://doi.org/10.1136/ard.2008.104315
Nishimoto, K. ; Kochi, Y. ; Ikari, K. ; Yamamoto, K. ; Suzuki, A. ; Shimane, K. ; Nakamura, Y. ; Yano, K. ; Iikuni, N. ; Tsukahara, S. ; Kamatani, N. ; Okamoto, H. ; Kaneko, H. ; Kawaguchi, Y. ; Hara, M. ; Toyama, Y. ; Horiuchi, T. ; Tao, K. ; Yasutomo, D. ; Yasui, N. ; Inoue, H. ; Itakura, M. ; Yamanaka, H. ; Momohara, S. / Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. :: Annals of the Rheumatic Diseases. 2010 ; 巻 69, 番号 2. pp. 368-373.
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abstract = "Objective: The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in Japanese populations. Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed. Methods: A multicentre association study consisting of 4 RA case-control series (4397 cases and 2857 controls) and 3 SLE case-control series (591 cases and 2199 shared controls) was conducted. Genotyping was performed using TaqMan genotyping assay for two single nucleotide polymorphisms (SNPs) that showed the best evidence of association in the previous Caucasian studies. Quantifications of TRAF1 and C5 expression were performed with TaqMan expression assay. Results: Significant differences in allele frequency for both SNPs were observed between RA and control subjects (combined odds ratio =1.09), while no significant difference was detected between patients with SLE and controls. Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies. A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetatestimulated lymphoblastoid cell lines (p=0.04). Conclusion: Association of TRAF1-C5 locus with RA susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for SLE. Significant positive effect of genotype on the expression of TRAF1 might support the genetic association between TRAF1 and RA.",
author = "K. Nishimoto and Y. Kochi and K. Ikari and K. Yamamoto and A. Suzuki and K. Shimane and Y. Nakamura and K. Yano and N. Iikuni and S. Tsukahara and N. Kamatani and H. Okamoto and H. Kaneko and Y. Kawaguchi and M. Hara and Y. Toyama and T. Horiuchi and K. Tao and D. Yasutomo and N. Yasui and H. Inoue and M. Itakura and H. Yamanaka and S. Momohara",
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T1 - Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

AU - Nishimoto, K.

AU - Kochi, Y.

AU - Ikari, K.

AU - Yamamoto, K.

AU - Suzuki, A.

AU - Shimane, K.

AU - Nakamura, Y.

AU - Yano, K.

AU - Iikuni, N.

AU - Tsukahara, S.

AU - Kamatani, N.

AU - Okamoto, H.

AU - Kaneko, H.

AU - Kawaguchi, Y.

AU - Hara, M.

AU - Toyama, Y.

AU - Horiuchi, T.

AU - Tao, K.

AU - Yasutomo, D.

AU - Yasui, N.

AU - Inoue, H.

AU - Itakura, M.

AU - Yamanaka, H.

AU - Momohara, S.

PY - 2010/2

Y1 - 2010/2

N2 - Objective: The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in Japanese populations. Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed. Methods: A multicentre association study consisting of 4 RA case-control series (4397 cases and 2857 controls) and 3 SLE case-control series (591 cases and 2199 shared controls) was conducted. Genotyping was performed using TaqMan genotyping assay for two single nucleotide polymorphisms (SNPs) that showed the best evidence of association in the previous Caucasian studies. Quantifications of TRAF1 and C5 expression were performed with TaqMan expression assay. Results: Significant differences in allele frequency for both SNPs were observed between RA and control subjects (combined odds ratio =1.09), while no significant difference was detected between patients with SLE and controls. Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies. A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetatestimulated lymphoblastoid cell lines (p=0.04). Conclusion: Association of TRAF1-C5 locus with RA susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for SLE. Significant positive effect of genotype on the expression of TRAF1 might support the genetic association between TRAF1 and RA.

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