Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Koji Yamanaka, Seung Joo Chun, Severine Boillee, Noriko Fujimori-Tonou, Hirofumi Yamashita, David H. Gutmann, Ryosuke Takahashi, Hidemi Misawa, Don W. Cleveland

研究成果: Article査読

804 被引用数 (Scopus)

抄録

Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial activation and sharply slowed later disease progression. These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS.

本文言語English
ページ(範囲)251-253
ページ数3
ジャーナルNature Neuroscience
11
3
DOI
出版ステータスPublished - 2008 3

ASJC Scopus subject areas

  • 神経科学(全般)

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