Asymmetric decarboxylation of α-hydroxy- and α-amino-α-phenylmalonate catalyzed by arylmalonate decarboxylase from Alcaligenes bronchisepticus

Keisuke Tamura, Yosuke Terao, Kenji Miyamoto, Hiromichi Ohta

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Arylmalonate decarboxylase (EC 4.1.1.76, from Alcaligenes bronchisepticus KU 1201) is an enzyme that catalyzes asymmetric decarboxylation of arylmalonate. The enzyme accepts as substrates compounds that have a sterically small hydrophobic α-substituent, such as H, F, and methyl. To widen the applicability of this enzyme and to obtain information on the interaction between the enzyme and substrates, we tried the reaction of compounds with a hydrophilic substituent. Although the relative reactivities were lower compared to that of phenylmalonate, α-hydroxy- and α-aminophenylmalonate were decarboxylated to give optically active monobasic acids.

本文言語English
ページ(範囲)253-257
ページ数5
ジャーナルBiocatalysis and Biotransformation
26
4
DOI
出版ステータスPublished - 2008 7

ASJC Scopus subject areas

  • バイオテクノロジー
  • 触媒
  • 生化学

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