Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

Masahiro Yokoyama; Takeshi Sugai; Hiromichi Ohta

doi:10.1016/S0957-4166(00)80214-1

Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

Masahiro Yokoyama, Takeshi Sugai, Hiromichi Ohta

薬科学科

研究成果: Article › 査読

47 被引用数 (Scopus)

抄録

Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

本文言語	English
ページ（範囲）	1081-1084
ページ数	4
ジャーナル	Tetrahedron: Asymmetry
巻	4
号	6
DOI	https://doi.org/10.1016/S0957-4166(00)80214-1
出版ステータス	Published - 1993 6月

ASJC Scopus subject areas

触媒
物理化学および理論化学
有機化学
無機化学

文献へのアクセス

10.1016/S0957-4166(00)80214-1

他のファイルとリンク

引用スタイル

@article{773b3103978e48e6a43fd592607bcd54,

title = "Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism",

abstract = "Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.",

author = "Masahiro Yokoyama and Takeshi Sugai and Hiromichi Ohta",

year = "1993",

month = jun,

doi = "10.1016/S0957-4166(00)80214-1",

language = "English",

volume = "4",

pages = "1081--1084",

journal = "Tetrahedron Asymmetry",

issn = "0957-4166",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

AU - Yokoyama, Masahiro

AU - Sugai, Takeshi

AU - Ohta, Hiromichi

PY - 1993/6

Y1 - 1993/6

N2 - Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

AB - Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

UR - http://www.scopus.com/inward/record.url?scp=0027280573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027280573&partnerID=8YFLogxK

U2 - 10.1016/S0957-4166(00)80214-1

DO - 10.1016/S0957-4166(00)80214-1

M3 - Article

AN - SCOPUS:0027280573

SN - 0957-4166

VL - 4

SP - 1081

EP - 1084

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 6

ER -

Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル