Asymmetric inheritance of radial glial fibers by cortical neurons

Takaki Miyata, Ayano Kawaguchi, Hideyuki Okano, Masaharu Ogawa

研究成果: Article査読

699 被引用数 (Scopus)

抄録

Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex. During RGC division, each pia-connected fiber becomes thin but is neither lost nor divided; it is inherited asymmetrically by one daughter cell. In divisions that produce a neuron and a progenitor, the neuron inherits the pial fiber, also grows a thick ventricular process for several hours, and is therefore indistinguishable from the progenitor RGC. The ventricular process in the radial glial-like neuron ("radial neuron") then collapses, leading to ascent of the neuron by using the "recycled" radial fiber.

本文言語English
ページ(範囲)727-741
ページ数15
ジャーナルNeuron
31
5
DOI
出版ステータスPublished - 2001 9月 13

ASJC Scopus subject areas

  • 神経科学(全般)

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