Asymmetric synthesis of isothiazoles through Cu catalysis: Direct catalytic asymmetric conjugate addition of allyl cyanide to α,β-unsaturated thioamides

Yuka Yanagida, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

47 被引用数 (Scopus)

抄録

Twice the catalyst: The simultaneous activation of an allyl cyanide (pronucleophile) and an α,β-unsaturated thioamide (electrophile) was achieved using a Cu-based soft Lewis acid/hard Brønsted base cooperative catalyst, thus resulting in the formation of enethioamides 1 in a highly enantio- and Z-selective manner (see scheme). The sequential Cu-catalyzed intramolecular cyclization gave rise to enantioenriched fused isothiazoles 2.

本文言語English
ページ(範囲)7910-7914
ページ数5
ジャーナルAngewandte Chemie - International Edition
50
34
DOI
出版ステータスPublished - 2011 8 16
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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