Asymmetric Synthesis of Protected Cyclohexenylamines and Cyclohexenols by Rhodium-Catalyzed [2+2+2] Cycloaddition

Koji Masutomi, Haruki Sugiyama, Hidehiro Uekusa, Yu Shibata, Ken Tanaka

研究成果: Article

12 引用 (Scopus)

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It has been established that cationic rhodium(I)/axially chiral biaryl bis(phosphine) complexes catalyze the asymmetric [2+2+2] cycloaddition of 1,6-enynes with electron-rich functionalized alkenes, enamides, and vinyl carboxylates, to produce the corresponding protected cyclohexenylamines and cyclohexenols. Interestingly, regioselectivity depends on structures of substrates. The present cycloaddition was successfully applied to the enantioselective total synthesis of (−)-porosadienone by using the amide moiety as a leaving group.

元の言語English
ページ(範囲)15373-15376
ページ数4
ジャーナルAngewandte Chemie - International Edition
55
発行部数49
DOI
出版物ステータスPublished - 2016 1 1
外部発表Yes

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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