Asymmetric Total Synthesis of Fasicularin by Chiral N-Alkoxyamide Strategy

Shio Yamamoto, Yukinori Komiya, Akihiro Kobayashi, Ryo Minamikawa, Takeshi Oishi, Takaaki Sato, Noritaka Chida

研究成果: Article査読

10 被引用数 (Scopus)

抄録

The asymmetric total synthesis of fasicularin is reported. The key to success is the use of a chiral N-alkoxyamide to control both reactivity and stereoselectivity. This functional group enables the aza-spirocyclization and the reductive Strecker reaction, which cannot be realized with an ordinary amide. In addition, use of the chiral alkoxy group establishes two consecutive stereocenters in the aza-spirocyclization through remote stereocontrol.

本文言語English
ページ(範囲)1868-1871
ページ数4
ジャーナルOrganic Letters
21
6
DOI
出版ステータスPublished - 2019 3 15

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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