ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children

Kenichiro Kobayashi, Kazumasa Mitsui, Hitoshi Ichikawa, Kazuhiko Nakabayashi, Masaki Matsuoka, Yasuko Kojima, Hiroyuki Takahashi, Kazutoshi Iijima, Kaori Ootsubo, Keisuke Oboki, Hajime Okita, Kazuki Yasuda, Hiromi Sakamoto, Kenichiro Hata, Teruhiko Yoshida, Kenji Matsumoto, Nobutaka Kiyokawa, Akira Ohara

研究成果: Article査読

30 被引用数 (Scopus)

抄録

We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.

本文言語English
ページ(範囲)836-841
ページ数6
ジャーナルBritish Journal of Haematology
165
6
DOI
出版ステータスPublished - 2014 6月
外部発表はい

ASJC Scopus subject areas

  • 血液学

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