Atrial natriuretic peptide in acute hypoxia-induced pulmonary hypertension in rats

H. Jin, R. H. Yang, Y. F. Chen, R. M. Jackson, H. Itoh, M. Mukoyama, K. Nakao, H. Imura, S. Oparil

研究成果: Article査読

38 被引用数 (Scopus)

抄録

To test the hypothesis that exogenous atrial natriuretic peptide (ANP) prevents the acute pulmonary pressor response to hypoxia, ANP (20-μg/kg bolus followed by 1-μg·kg-1·min-1 infusion) or vehicle was administered intravenously to conscious rats beginning 3 min before exposure to hypoxia or room air for 90 min. Exogenous ANP abolished the acute pulmonary pressor response to hypoxia in association with marked and parallel increases in plasma ANP and guanosine 5'-cyclic monophosphate (cGMP) and with a significant increase in lung cGMP content. To examine whether endogenous ANP modulates the acute pulmonary pressor response to hypoxia, rats were pretreated with a monoclonal antibody (Ab) to ANP and exposed to hypoxia. Mean pulmonary arterial pressure (MPAP) in the Ab-treated rats was not different from control over the first 6 h of hypoxic exposure. Thereafter, the Ab-treated group had significantly higher MPAP than control. Our data suggest that 1) exogenous ANP blocks the pulmonary pressor response to acute hypoxia via stimulation of cGMP accumulation in the pulmonary vasculature, and 2) endogenous ANP may modulate the subacute, but not acute, phase of hypoxic pulmonary hypertension.

本文言語English
ページ(範囲)807-814
ページ数8
ジャーナルJournal of Applied Physiology
71
3
DOI
出版ステータスPublished - 1991
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 生理学(医学)

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