Atrial natriuretic polypeptide in spinal cord and autonomic ganglia

Narito Morii, Kazuwa Nakao, Hiroshi Itoh, Shozo Shiono, Takayuki Yamada, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Makoto Sakamoto, Hiroo Imura

研究成果: Article査読

39 被引用数 (Scopus)

抄録

Using a radioimmunoassay for α-rat atrial natriuretic polypeptide (α-rANP), tissue levels of α-rANP-like immunoreactivity (-LI) in the rat spinal cord and autonomic ganglia were investigated. The α-rANP-LI level was higher in the more caudal parts of the spinal cord and the highest in the sacral spinal cord. α-rANP-LI was also detected in the superior cervical and coeliac ganglia. Gel permeation chromatographic analysis showed that the major peak of α-rANP-LI in the spinal cord was a low molecular weight form co-eluted with synthetic α-rANP. Reverse-phase high performance liquid chromatographic analysis revealed that α-rANP-LI with a low molecular weight in the spinal cord consisted of several components, two major components of which co-migrated with synthetic α-rANP(4-28) and α-rANP(5-28), whereas little immunoreactivity was eluted at the position of α-rANP. These findings suggest the involvement of ANP in the function of the spinal cord and autonomic nervous system.

本文言語English
ページ(範囲)196-203
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
145
1
DOI
出版ステータスPublished - 1987 5月 29
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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