Atrial natriuretic polypeptides: Structure-activity relationship in the central action - a comparison of their antidipsogenic actions

Hiroshi Itoh, Kazuwa Nakao, Goro Katsuura, Narito Morii, Shozo Shiono, Takayuki Yamada, Akira Sugawara, Yoshihiko Saito, Kunio Watanabe, Kenichi Igano, Ken Inouye, Hiroo Imura

研究成果: Article査読

22 被引用数 (Scopus)

抄録

The structure-activity relationship of atrial natriuretic polypeptides (ANPs) in the central action was investigated by examining the suppressive effects of the intracerebroventricular (i.c.v.) administration of ANPs on water intake induced by the i.c.v. injection of angiotensin II (AII) (0.1 nmol) in rats. α-Rat ANP (α-rANP), α-human ANP, α-rANP4-28 and α-rANP5-28 at a dose of 1.5 nmol exerted equipotent antidipsogenic actions, while α-rANP7-23-amide had no inhibitory effect on water drinking at this dose.

本文言語English
ページ(範囲)102-106
ページ数5
ジャーナルNeuroscience Letters
74
1
DOI
出版ステータスPublished - 1987 2 10
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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