The structure-activity relationship of atrial natriuretic polypeptides (ANPs) in the central action was investigated by examining the suppressive effects of the intracerebroventricular (i.c.v.) administration of ANPs on water intake induced by the i.c.v. injection of angiotensin II (AII) (0.1 nmol) in rats. α-Rat ANP (α-rANP), α-human ANP, α-rANP4-28 and α-rANP5-28 at a dose of 1.5 nmol exerted equipotent antidipsogenic actions, while α-rANP7-23-amide had no inhibitory effect on water drinking at this dose.
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