Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction

Shinya Goto, Shunnosuke Handa, Yohko Kawai, Kiyoaki Watanabe, Sumihisa Abe, Eiichi Takahashi, Shingo Hori, Yasuo Ikeda

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemos-tases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrom-bin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein Cactivity.

本文言語English
ページ(範囲)252-256
ページ数5
ジャーナルCardiology (Switzerland)
80
3-4
DOI
出版ステータスPublished - 1992
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学
  • 薬理学(医学)

フィンガープリント

「Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル