TY - JOUR
T1 - Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts
AU - Sugawara, Akira
AU - Nakao, Kazuwa
AU - Morii, Narito
AU - Yamada, Takayuki
AU - Itoh, Hiroshi
AU - Shiono, Shozo
AU - Saito, Yoshihiko
AU - Mukoyama, Masashi
AU - Arai, Hiroshi
AU - Nishimura, Kazunobu
AU - Obata, Kenji
AU - Yasue, Hirofumi
AU - Ban, Toshihiko
AU - Imura, Hiroo
N1 - Funding Information:
We are indebted to Professor Hisayuki Mdtsuo and Dr. Kenji Kangawa, Department of Biochemistry, Miyazaki Medical College, Miyazaki, for generous supply of cr-hANP, to Dr. Ken Inouye, Shionogi Research Laboratories, Shionogi Co., Ltd., Osaka. for donation of B-hANP. We also thank Mrs. Hiroko Tabata and Miss Atsuko Furu for their secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare "Disorders of Adrenal Hormone" Research Committee, Japan, 1987, Japan Tobacco Inc. and Yamanouchi Foundation for Research on Metabolic Disorders, by a research grant for cardiovascular diseases ((60A-3) and (62A-1)) from the Japanese Ministry of Health and Welfare.
PY - 1988/1/15
Y1 - 1988/1/15
N2 - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.
AB - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.
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U2 - 10.1016/0006-291X(88)90486-X
DO - 10.1016/0006-291X(88)90486-X
M3 - Article
C2 - 2962584
AN - SCOPUS:0023868313
SN - 0006-291X
VL - 150
SP - 60
EP - 67
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -