Aurora-A - A guardian of poles

Tomotoshi Marumoto, Dongwei Zhang, Hideyuki Saya

研究成果: Review article査読

586 被引用数 (Scopus)

抄録

The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

本文言語English
ページ(範囲)42-50
ページ数9
ジャーナルNature Reviews Cancer
5
1
DOI
出版ステータスPublished - 2005 1
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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