Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion

Masayuki Amagai, Vera Klaus-Kovtun, John R. Stanley

研究成果: Article査読

858 被引用数 (Scopus)

抄録

Pemphigus vulgaris (PV) is a life-threatening skin disease in which autoantibodies against a keratinocyte cell surface 130 kd glycoprotein, PV antigen (PVA), cause loss of cell-cell adhesion, with resultant epidermal blisters. We used affinity-purified PV lgG to isolate cDNA, containing the entire coding sequence for PVA, from human keratinocyte expression libraries. Northern blot analysis indicated PV mRNA expression only in stratified squamous epithelia. The deduced amino acid sequence of PVA was unique but showed significant homology with members of the cadherin family of Ca2+-dependent cell adhesion molecules, most markedly to desmoglein I. These findings demonstrate that a novel epithelial cadherin is the target of autoantibodies in PV.

本文言語English
ページ(範囲)869-877
ページ数9
ジャーナルCell
67
5
DOI
出版ステータスPublished - 1991 11月 29
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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