Autoantibodies against Forssman glycolipids in Graves' disease and Hashimoto's thyroiditis

T. ARIGA, T. YOSHIDA, T. MIMORI, R. K. YU

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Sera from patients with Graves’ disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin‐layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves’ disease. A MoAb, TRMo‐4, reacted strongly and specifically with Gb5. These results suggest that anti‐Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti‐Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.

本文言語English
ページ(範囲)483-488
ページ数6
ジャーナルClinical & Experimental Immunology
86
3
DOI
出版ステータスPublished - 1991 12

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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