Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis

Shigeaki Suzuki, Kimiaki Utsugisawa, Kazuo Iwasa, Takashi Satoh, Yuriko Nagane, Hiroaki Yoshikawa, Masataka Kuwana, Norihiro Suzuki

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Immune responses to ER stress have been closely related to the pathogenesis of autoimmune diseases. Using an immunoprecipitation assay, 24 (7.1%) of 336 MG serum samples immunoprecipitated a 90-kDa protein from the muscle cellular extracts, but none of the disease or healthy control sera. The 90-kDa protein was affinity-purified and found to match to ER chaperon GRP94 by matrix-assisted laser desorption/ionization-time of flight mass spectroscopy analysis. The frequency of associated autoimmune diseases was much higher in the anti-GRP94-positive than the -negative patients (71% versus 11%, p < 0.001). Autoimmunity to ER chaperone GRP94 is associated with a subset of MG patients who have additional autoimmune diseases.

本文言語English
ページ(範囲)87-92
ページ数6
ジャーナルJournal of Neuroimmunology
237
1-2
DOI
出版ステータスPublished - 2011 8月 15

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

フィンガープリント

「Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル