Autophagic control of listeria through intracellular innate immune recognition in drosophila

Tamaki Yano, Shizuka Mita, Hiroko Ohmori, Yoshiteru Oshima, Yukari Fujimoto, Ryu Ueda, Haruhiko Takada, William E. Goldman, Koichi Fukase, Neal Silverman, Tamotsu Yoshimori, Shoichiro Kurata

研究成果: Article査読

281 被引用数 (Scopus)

抄録

Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic components, has been linked to the elimination of intracellular pathogens during mammalian innate immune responses. However, the mechanisms underlying cytoplasmic infection-induced autophagy and the function of autophagy in host survival after infection with intracellular pathogens remain unknown. Here we report that in drosophila, recognition of diaminopimelic acid-type peptidoglycan by the pattern-recognition receptor PGRP-LE was crucial for the induction of autophagy and that autophagy prevented the intracellular growth of Listeria monocytogenes and promoted host survival after this infection. Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense.

本文言語English
ページ(範囲)908-916
ページ数9
ジャーナルNature Immunology
9
8
DOI
出版ステータスPublished - 2008 8
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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