Autophagy

Hitoshi Tsugawa, Hidekazu Suzuki

研究成果: Chapter

抄録

Autophagy is a eukaryotic, nonspecific degradation mechanism and serves as part of the innate immune system of host cells. In Helicobacter pylori-infected host cells, autophagy is activated by the bacterial vacuolating cytotoxin A (VacA) via the following pathway: VacA binds to low-density lipoprotein receptor-related protein-1, induces intracellular glutathione deficiency, and enhances activation of protein kinase B (Akt), which in turn induces Mdm2-mediated p53 degradation and then activates autophagy. Translocated bacterial proteins, VacA and CagA, are degraded by autophagy. However, autophagy is not activated in the CD44v9-expressing gastric cancer stem-like cells, leading to the specific accumulation of intracellular CagA. Therefore, the presence of CD44v9-expressing cells in H. pylori-infected patients is associated with the risk of developing gastric cancer. Autophagy in the host gastric epithelial cells plays an important role in H. pylori infectious disease via degradation of VacA and CagA.

元の言語English
ホスト出版物のタイトルHelicobacter Pylori
出版者Springer Japan
ページ67-71
ページ数5
ISBN(電子版)9784431557050
ISBN(印刷物)9784431557043
DOI
出版物ステータスPublished - 2016 1 1

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Autophagy
Cytotoxins
Helicobacter pylori
Stomach Neoplasms
Low Density Lipoprotein Receptor-Related Protein-1
Proto-Oncogene Proteins c-akt
Bacterial Proteins
Neoplastic Stem Cells
Communicable Diseases
Glutathione
Immune System
Stomach
Epithelial Cells

ASJC Scopus subject areas

  • Medicine(all)

これを引用

Tsugawa, H., & Suzuki, H. (2016). Autophagy. : Helicobacter Pylori (pp. 67-71). Springer Japan. https://doi.org/10.1007/978-4-431-55705-0_5

Autophagy. / Tsugawa, Hitoshi; Suzuki, Hidekazu.

Helicobacter Pylori. Springer Japan, 2016. p. 67-71.

研究成果: Chapter

Tsugawa, H & Suzuki, H 2016, Autophagy. : Helicobacter Pylori. Springer Japan, pp. 67-71. https://doi.org/10.1007/978-4-431-55705-0_5
Tsugawa H, Suzuki H. Autophagy. : Helicobacter Pylori. Springer Japan. 2016. p. 67-71 https://doi.org/10.1007/978-4-431-55705-0_5
Tsugawa, Hitoshi ; Suzuki, Hidekazu. / Autophagy. Helicobacter Pylori. Springer Japan, 2016. pp. 67-71
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