Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis

Shigeaki Suzuki, Kortaro Tanaka, Hidekata Yasuoka, Yasuo Fukuuchi, Yutaka Kawakami, Masataka Kuwana

研究成果: Article査読

6 被引用数 (Scopus)

抄録

In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.

本文言語English
ページ(範囲)177-186
ページ数10
ジャーナルJournal of Neuroimmunology
137
1-2
DOI
出版ステータスPublished - 2003 4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

フィンガープリント 「Autoreactive T cells to the P3A<sup>+</sup> isoform of AChR α subunit in myasthenia gravis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル