Azaelectrocyclization on cell surface: Convenient and general approach to chemical biology research

Akihiro Ogura, Katsunori Tanaka

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Convenient and general method for live cell surface labeling was established. Azide-containing fluorescences were initially conjugated with the unsaturated ester aldehyde containing the dibenzocyclooctyne (DIBO), by the strain-promoted click reaction. The resulting probes were then treated with the live cells in one-pot process, efficiently labeling the surface lysines by azaelectrocyclization under the mild conditions.

本文言語English
ページ(範囲)4518-4521
ページ数4
ジャーナルTetrahedron
71
26-27
DOI
出版ステータスPublished - 2015 5月 30
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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