抄録
B cells generated early during fetal/neonatal B-1 development in mice include autoreactive cells with detectable CD5 upregulation induced by B cell receptor (BCR) signaling (B1a cells). A fraction of B1a cells are maintained by self-renewal for life, with the potential risk of dysregulated growth and progression to chronic lymphocytic leukemia (CLL)/lymphoma during aging. In studies using the Eμ-hTCL1 transgenic mouse system, it became clear that this B1a subset has a higher potential than other B cell subsets for progression to CLL. We have generated several autoreactive germline BCR gene models to compare B cells generated under conditions of natural exposure to autoantigen. Analysis of the mice has been key in understanding the importance of the BCR and BCR signaling for generating different B cell subsets and for investigating the cellular origin of B-CLL.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 250-255 |
| ページ数 | 6 |
| ジャーナル | Annals of the New York Academy of Sciences |
| 巻 | 1362 |
| 号 | 1 |
| DOI | |
| 出版ステータス | Published - 2015 12月 1 |
ASJC Scopus subject areas
- 神経科学（全般）
- 生化学、遺伝学、分子生物学（全般）
- 科学史および科学哲学