Bacillus subtilis epoxide hydrolase-catalyzed preparation of enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-bicalutamide

Aya Fujino, Masayoshi Asano, Hitomi Yamaguchi, Naoki Shirasaka, Akiko Sakoda, Masaya Ikunaka, Rika Obata, Shigeru Nishiyama, Takeshi Sugai

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Expeditious synthesis of (R)-bicalutamide (1), a synthetic antiandrogen, from enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether (4) was achieved. An engineered Bacillus subtilis epoxide hydrolase worked enantioselectively on the racemic epoxide (7) to provide the above starting material in highly enantiomerically enriched state.

本文言語English
ページ(範囲)979-983
ページ数5
ジャーナルTetrahedron Letters
48
6
DOI
出版ステータスPublished - 2007 2 5

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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