Backbone and side chain assignments of the second RNA-binding domain of Musashi-1 in its free form and in complex with 5-mer RNA

Ryo Iwaoka, Takashi Nagata, Kengo Tsuda, Takao Imai, Hideyuki Okano, Naohiro Kobayashi, Masato Katahira

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Musashi1 (Msi1) is an RNA-binding protein that is involved in cell fate determination. Here, we report the 1H, 15N, and 13C resonance assignments of Msi1 second RNA-binding domain in free form and in complex with RNA. The assignments can be utilized for NMR structure and dynamics analyses of the Msi1:RNA complex, and moreover, for chemical shift perturbation analyses to evaluate the binding of potential small molecule inhibitors against Msi1:RNA interaction.

本文言語English
ページ(範囲)265-268
ページ数4
ジャーナルBiomolecular NMR Assignments
11
2
DOI
出版ステータスPublished - 2017 10月 1

ASJC Scopus subject areas

  • 構造生物学
  • 生化学

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