Bacterial proteolytic activity improves drug delivery in tumors in a size, pharmacokinetic, and binding affinity dependent manner – A mechanistic understanding

Chemical Compounds

• Doxorubicin 100%
• Kd 72%
• Pharmacokinetics 72%
• Antineoplastic Agent 63%
• Drug 50%
• Interstitial 50%
• Hydraulic Conductivity 40%
• Collagen 22%
• Permeability 19%
• Flow 15%
• Pressure 13%

Medicine & Life Sciences

• Pharmacokinetics 72%
• liposomal doxorubicin 60%
• Doxorubicin 59%
• Bacteria 43%
• Pharmaceutical Preparations 39%
• Neoplasms 31%
• Convection 30%
• Blood Vessels 12%
• Extracellular Fluid 12%
• Capillary Permeability 11%
• Extracellular Matrix 9%
• Collagen 8%
• Research Personnel 7%
• Therapeutics 6%
• Pressure 6%
• Drug Therapy 6%