Baroreceptor sensitivity during the compensatory phase of left ventricular overloading

Hiroshi Nishimura, Tsutomu Yoshikawa, Toshihisa Anzai, Akiyasu Baba, Natsuki Kobayashi, Yumiko Wainai, Satoshi Ogawa

研究成果: Article

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This study focused on the role of the baroreceptor-mediated control during the compensatory process after acute left ventricular overloading induced by aortic regurgitation (AR). Baroreceptor-heart rate sensitivity was measured using a phenylephrine-induced increase in blood pressure according to the steady state method before, 1 day, 1 week and 4 weeks after production of AR in 7 rabbits, and compared with 6 other rabbits that underwent a sham operation. Blood pressure was monitored noninvasively using Finapres in the unanesthetized state. Four weeks after the procedure, the left ventricular diameters of both end-diastole and end-systole were larger in the rabbits with AR than in the sham-operated rabbits. There was no difference in the left ventricular end-diastolic pressure or cardiac output. Left ventricular weight was higher in the rabbits with AR than in the sham-operated rabbits. Myocardial β-adrenergic receptor density and norepinephrine content were comparable between the two groups. Baroreceptor-heart rate sensitivity significantly decreased 1 week after production of AR, and this alteration in sensitivity was partially restored 4 weeks after production of AR. These findings suggested that the altered baroreceptor-heart rate sensitivity was reversible, relating to the compensatory process after acute left ventricular overloading, and that these changes had some role in its pathophysiology.

元の言語English
ページ(範囲)773-778
ページ数6
ジャーナルJAPANESE CIRCULATION JOURNAL
62
発行部数10
DOI
出版物ステータスPublished - 1998 10 1

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Nishimura, H., Yoshikawa, T., Anzai, T., Baba, A., Kobayashi, N., Wainai, Y., & Ogawa, S. (1998). Baroreceptor sensitivity during the compensatory phase of left ventricular overloading. JAPANESE CIRCULATION JOURNAL, 62(10), 773-778. https://doi.org/10.1253/jcj.62.773