Base liberation from nucleotides by superoxide and intramolecular enhancement effect of phosphate group

Hiroshi Yamane, Nobuhisa Yada, Etsu Katori, Tadahiko Mashino, Tetsuo Nagano, Masaaki Hirobe

研究成果: Article

17 被引用数 (Scopus)

抄録

The reaction of nucleotides with superoxide gave the corresponding nucleobases in good yield. The base-release reaction of nucleotides due to superoxide was examined and compared to that of nucleosides. Hence, the phosphate moiety greatly enhances the yields, in particular those of adenine from adenosine monophosphates. Superoxide in combination with the phosphate moiety has been revealed to be more active than superoxide alone. The phosphate peroxy radical, generated in situ from superoxide and phosphate, seems to be the species responsible for the formation of the free bases.

本文言語English
ページ(範囲)1104-1110
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
142
3
DOI
出版ステータスPublished - 1987 2 13
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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