Basic and clinical examinations of latamoxef in neonates and immature infants

Masahiro Tojo, Keisuke Sunakawa, Seiichiro Nanri, Hironobu Akita, Satoshi Iwata, Yukio Iwasaki, Takefumi Kanemtisu, Yoshitake Satoh, Tadao Oikawa, Mitsuru Osano, Yasuo Ichihashi, Kazuo Ishikawa, Kensuke Shirane, Makoto Hirose, Hiroyuki Tsuchiya, Yutaka Taguchi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Latamoxef (LMOX) was used in the treatment and prophylaxis of infections in neonates and immature infants. The following results were obtained. 1. Mean serum concentrations (bioassay) 30 minutes after a single intravenous injection of about 20 mg/kg of LMOX were 49.9mcg/ml in neonates and 47.3mcg/ml in immature infants aged 0-3 days, 54.1 mcg/ml in neonates and 60.6mcg/ml in immature infants aged 4~7 days, 48.9mcg/ml in neonates and 46.7 mcg/ml in immature infants aged 8-28 days and 62.1 mcg/ml in immature infants aged over 29 days. Six-hour values were 24.1 mcg/ml, 22.5 mcg/ml, 15.9 mcg/ml, 27.2 mcg/ml, 12.9 mcg/ml, 19.1 mcg/ml and 12.8 mcg/ml, respectively. 2. Mean serum concentration half-lives were 6.70 hotirs in neonates and 8.16 hours in immature infants ggcH 0-3 days, 3.68 hours in neonates and 5.83 hours in immature infants aged 4-7 days, 3.06 hours in neonates and 4.47 hours in immature infants aged 8-28 days and 2.59 hours in immature infants aged over 29 days. 3. Adequate Hiniral efficacy can be expected by the intravenous injection of LMOX in doses of 20 mg/kg 1-2 times daily, in neonates and immature infants aged 0�3 days, 20 mg/kg 2�3 times daily, in neonates and immature infants aged 4-7 days and 20 mg/kg 3 times daily, in neonates and immature infants aged 8-28 4. The clinical efficacy of LMOX was good in 5 cases of sepsis (including suspected cases), 5 cases of urinary tract infection, 2 cases of respitary tract infection and 6 cases of intrauterine urfection (including suspected cases). Oiily a case of respiratory tract infections due to P. aeruginosa was thought to be ineffective. 5. Bleeding tendency was noted in 3 cases, which results from secondary vitamin K deficiency should be checked carefully during the administration of LMOX.

本文言語English
ページ(範囲)2312-2321
ページ数10
ジャーナルthe japanese journal of antibiotics
36
9
DOI
出版ステータスPublished - 1983 1 1

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

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