抄録
The members of ICE/CED3 family of cysteine proteases (caspases) play important roles in the regulation of programmed cell death. Recent studies have revealed that processing and activation of CPP32 (CASP-3) are crucial for executing cell death in TNF-α- and Fas-induced apoptosis. Overexpression of Bcl-2 in HeLa cells inhibits the cell death and CASP-3 like protease activities which are induced by TNF-α or anti-Fas antibody. Preform of CASP-3 disappered after the treatment with TNF-α or anti-Fas antibody in both HeLa cells and HeLa/bcl-2 cells. These results suggest Bcl-2 prevents cell death and activation of CASP-3 but does not inhibit initial processing of CASP-3.
本文言語 | English |
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ページ(範囲) | 405-411 |
ページ数 | 7 |
ジャーナル | Biomedical Research |
巻 | 18 |
号 | 6 |
DOI | |
出版ステータス | Published - 1997 12月 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学、遺伝学、分子生物学(全般)