Beta-cell mass in obesity and type 2 diabetes, and its relation to pancreas fat: A mini-review

研究成果: Review article査読

7 被引用数 (Scopus)

抄録

Type 2 diabetes (T2DM) is characterized by insulin resistance and beta-cell dysfunction. Although insulin resistance is assumed to be a main pathophysiological feature of the development of T2DM, recent studies have revealed that a deficit of functional beta-cell mass is an essential factor for the pathophysiology of T2DM. Pancreatic fat contents increase with obesity and are suggested to cause beta-cell dysfunction. Since the beta-cell dysfunction induced by obesity or progressive decline with disease duration results in a worsening glycemic control, and treatment failure, preserving beta-cell mass is an important treatment strategy for T2DM. In this mini-review, we summarize the current knowledge on beta-cell mass, beta-cell function, and pancreas fat in obesity and T2DM, and we discuss treatment strategies for T2DM in relation to beta-cell preservation.

本文言語English
論文番号3846
ページ(範囲)1-16
ページ数16
ジャーナルNutrients
12
12
DOI
出版ステータスPublished - 2020 12

ASJC Scopus subject areas

  • 食品科学
  • 栄養および糖尿病

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