Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tatsuya Nishihara; Satoshi Kuno; Hiroshi Nonaka; Sho Tabata; Natsumi Saito; Shinji Fukuda; Masaru Tomita; Shinsuke Sando; Tomoyoshi Soga

doi:10.1039/c8cc06068a

Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tatsuya Nishihara, Satoshi Kuno, Hiroshi Nonaka, Sho Tabata, Natsumi Saito, Shinji Fukuda, Masaru Tomita, Shinsuke Sando, Tomoyoshi Soga

環境情報学部

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

本文言語	English
ページ（範囲）	11745-11748
ページ数	4
ジャーナル	Chemical Communications
巻	54
号	83
DOI	https://doi.org/10.1039/c8cc06068a
出版ステータス	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

文献へのアクセス

10.1039/c8cc06068a

他のファイルとリンク

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引用スタイル

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AU - Nishihara, Tatsuya

AU - Kuno, Satoshi

AU - Nonaka, Hiroshi

AU - Tabata, Sho

AU - Saito, Natsumi

AU - Fukuda, Shinji

AU - Tomita, Masaru

AU - Sando, Shinsuke

AU - Soga, Tomoyoshi

PY - 2018

Y1 - 2018

N2 - Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

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