Bilateral coherence between motor cortices and subthalamic nuclei in patients with Parkinson's disease

Kenji Kato, Fusako Yokochi, Makoto Taniguchi, Ryoichi Okiyama, Takashi Kawasaki, Katsuo Kimura, Junichi Ushiba

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Objective: It has been suggested that abnormal synchronization and oscillation of neuronal activity in the subthalamic nucleus (STN) is associated with sensorimotor dysfunction in Parkinson's disease (PD). We investigated the bilateral subcortico-cortical functional coupling in PD patients. Methods: We simultaneously recorded local field potentials from the bilateral STN using electrodes inserted for deep brain stimulation and electroencephalograms from the bilateral motor cortices (MCx) in 11 patients at rest, and analyzed their coherences and causalities. Results: Significant coherence in the sub-beta and beta frequency bands was simultaneously observed between the STN and contralateral STN (STN-cSTN), the STN and ipsilateral MCx (STN-iMCx), and the STN and contralateral MCx (STN-cMCx). In each patient, the frequency of the peak STN-cSTN coherence was similar to that of the peak STN-iMCx and STN-cMCx coherence. The causality between the STN and MCx was strongest in the one-way direction from the MCx to the ipsilateral STN. Conclusions: Abnormal oscillations in the STN in the sub-beta and beta bands were functionally coupled among bilateral STN and MCx at the eigen-frequency in individual patients with PD. Significance: Synchronized activity through cortico-subcortical transmission may have an important role in the pathophysiology of PD.

本文言語English
ページ(範囲)1941-1950
ページ数10
ジャーナルClinical Neurophysiology
126
10
DOI
出版ステータスPublished - 2015 10 1

ASJC Scopus subject areas

  • 感覚系
  • 神経学
  • 臨床神経学
  • 生理学(医学)

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