Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2

Daryono H. Tjahjono, Suhendar, Benny Permana, Naoki Yoshioka, Hidenari Inoue

研究成果: Article査読

抄録

The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) 2 and poly(dA-dT) 2 has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) 2 but outside bound to the major groove of poly(dA-dT) 2. The binding constants of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 are in the order of 10 6 M -1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 is endothermic and entropically driven.

本文言語English
ページ(範囲)305-313
ページ数9
ジャーナルJournal of Porphyrins and Phthalocyanines
14
4
DOI
出版ステータスPublished - 2010 4月

ASJC Scopus subject areas

  • 化学 (全般)

フィンガープリント

「Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル