TY - JOUR
T1 - Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2
AU - Tjahjono, Daryono H.
AU - Suhendar,
AU - Permana, Benny
AU - Yoshioka, Naoki
AU - Inoue, Hidenari
N1 - Funding Information:
This research was supported in part by a Grant-in-Aid for Scientific Research (No. 13554025) from the Ministry of Education, Science, Sports, and Culture of the Japanese Government, KK ITB Research Grant 2007, Competitive Research Grant (HB XVI/2008) and Competence Grant 2009 from the Ministry of National Education of the Indonesian Government. D.H.T. wishes to thank The Hitachi Scholarship Foundation, Tokyo, Japan for financial support through the Hitachi Research Fellowship 2008.
PY - 2010/4
Y1 - 2010/4
N2 - The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) 2 and poly(dA-dT) 2 has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) 2 but outside bound to the major groove of poly(dA-dT) 2. The binding constants of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 are in the order of 10 6 M -1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 is endothermic and entropically driven.
AB - The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) 2 and poly(dA-dT) 2 has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) 2 but outside bound to the major groove of poly(dA-dT) 2. The binding constants of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 are in the order of 10 6 M -1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 is endothermic and entropically driven.
KW - Metallopyrazolium-4-ylporphyrin
KW - Poly(dA-dT)
KW - Poly(dG-dC)
KW - Porphyrin-DNA interaction
KW - Thermodynamic parameters
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U2 - 10.1142/S1088424610002148
DO - 10.1142/S1088424610002148
M3 - Article
AN - SCOPUS:77953849798
VL - 14
SP - 305
EP - 313
JO - Journal of Porphyrins and Phthalocyanines
JF - Journal of Porphyrins and Phthalocyanines
SN - 1088-4246
IS - 4
ER -