Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2

Daryono H. Tjahjono; Suhendar; Benny Permana; Naoki Yoshioka; Hidenari Inoue

doi:10.1142/S1088424610002148

Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) ₂ and poly(dA-dT) ₂

Daryono H. Tjahjono, Suhendar, Benny Permana, Naoki Yoshioka, Hidenari Inoue

応用化学科

研究成果: Article

抜粋

The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) ₂ and poly(dA-dT) ₂ has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) ₂ but outside bound to the major groove of poly(dA-dT) ₂. The binding constants of NiPzP to poly(dG-dC) ₂ and poly(dA-dT) ₂ are in the order of 10 ⁶ M ^-1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) ₂ and poly(dA-dT) ₂ is endothermic and entropically driven.

元の言語	English
ページ（範囲）	305-313
ページ数	9
ジャーナル	Journal of Porphyrins and Phthalocyanines
巻	14
発行部数	4
DOI	https://doi.org/10.1142/S1088424610002148
出版物ステータス	Published - 2010 4

ASJC Scopus subject areas

Chemistry(all)

文献にアクセス

10.1142/S1088424610002148

フィンガープリント Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) <sub>2</sub> and poly(dA-dT) <sub>2</sub>' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

これを引用

Tjahjono, D. H., Suhendar, Permana, B., Yoshioka, N., & Inoue, H. (2010). Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) ₂ and poly(dA-dT) ₂. Journal of Porphyrins and Phthalocyanines, 14(4), 305-313. https://doi.org/10.1142/S1088424610002148

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abstract = "The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) 2 and poly(dA-dT) 2 has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) 2 but outside bound to the major groove of poly(dA-dT) 2. The binding constants of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 are in the order of 10 6 M -1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 is endothermic and entropically driven.",

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AU - Tjahjono, Daryono H.

AU - Suhendar,

AU - Permana, Benny

AU - Yoshioka, Naoki

AU - Inoue, Hidenari

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AB - The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) 2 and poly(dA-dT) 2 has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) 2 but outside bound to the major groove of poly(dA-dT) 2. The binding constants of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 are in the order of 10 6 M -1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 is endothermic and entropically driven.

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KW - Thermodynamic parameters

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