Bioactive secondary metabolites from symbiotic marine dinoflagellates: Symbiodinolide and durinskiols

Masaki Kita, Osamu Ohno, Chunguang Han, Daisuke Uemura

研究成果: Review article査読

28 被引用数 (Scopus)

抄録

Symbiotic relationships play critical roles in marine ecosystems. Among symbionts, marine dinoflagellates have attracted the attention of natural products chemists, biologists, and ecologists, since they are rich sources of unique bioactive secondary metabolites. The polyol compound symbiodinolide, which was isolated from the symbiotic dinoflagellate Symbiodinium sp., exhibits significant voltage-dependent N-type Ca2+ channel-opening activity and may serve as a defense substance to prevent digestion of the host animals. Durinskiols are also unique long carbon-chain polyol compounds that were isolated from the dinoflagellate Durinskia sp. We found a selective cleavage reaction of allylic 1,2-diol using an olefin metathesis catalyst, and developed a fluorescent-labeling method for MS/MS analysis to achieve the structural elucidation of huge polyol compounds. This review highlights recent advances in structural and biological studies on symbiodinolide, durinskiols, and related polyol compounds.

本文言語English
ページ(範囲)57-69
ページ数13
ジャーナルChemical Record
10
2
DOI
出版ステータスPublished - 2010 4月
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 生化学
  • 化学工学(全般)
  • 材料化学

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