Bioassay-guided isolation of compounds from Datura stramonium with TRAIL-resistance overcoming activity

Utpal K. Karmakar, Kazufumi Toume, Naoki Ishikawa, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

TRAIL is a potent inducer of apoptosis in most cancer cells, but not in normal cells, and therefore has deserved intense interest as a promising agent for cancer therapy. In the search for bioactive natural products for overcoming TRAIL-resistance, we previously reported a number of active compounds. In our screening program on natural resources targeting overcoming TRAIL-resistance, activity-guided fractionation of the MeOH extract of Datura stramonium leaves led to the isolation of three alkaloids - scopolamine (1), trigonelline (2), and tyramine (3). Compounds 1, 2, and 3 exhibited TRAIL-resistance overcoming activity at 50, 150, and 100 μM, respectively in TRAIL-resistant AGS cells.

本文言語English
ページ(範囲)185-187
ページ数3
ジャーナルNatural product communications
11
2
DOI
出版ステータスPublished - 2016 2月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 植物科学
  • 創薬
  • 補完代替医療

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