Biocatalysis in Organic Synthesis: The Use of Nitrile- and Amide-hydrolyzing Microorganisms

Takeshi Sugai, Takahiro Yamazaki, Masahiro Yokoyama, Hiromichi Ohta

研究成果: Article査読

124 被引用数 (Scopus)

抄録

This review covers recent examples of synthetic transformation of nitriles and amides by microbial enzyme systems. A variety of substrates and products involving enantiomerically enriched forms of chiral substances are referred to. The stereochemical course of enzyme-catalyzed hydrolysis is briefly commented on. Special emphasis is placed upon the range of functional groups that are acceptable by enzymes and/or survive under the transformation, as well as the advantages as a synthetic tool for conversion under mild conditions.

本文言語English
ページ(範囲)1419-1427
ページ数9
ジャーナルBioscience, Biotechnology and Biochemistry
61
9
DOI
出版ステータスPublished - 1997 1

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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