Biocatalytic preparation of (R)-(-)-4-(phenylthio)-2-butanol and (R)-(-)-4-(Phenylsulfonyl)-2-butanol by the sequential use of Pichia farinosa and Rhodococcus rhodochrous

Takeshi Sugai, Yoshikazu Ohtsuka, Hiromichi Ohta

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Preparation of (R)-4-(phenylthio)-2-butanol and (R)-4-(phenylsulfonyl)-2-butanol has been established based on the sequential use of two biocatalysts. A Pichia farinosa IAM 4682 mediated reduction of 4-(phenylthio)-2-butanone afforded (R)-4-(phenylthio)-2-butanol (91%e.e.) in 90% yield. Contaminating (S)-enantiomer in the resulting product was selectively oxidized by Rhodococcus rhodochrous IFO15564 to leave pure (R)-enantiomer in 87% yield. From this product, highly enantiomerically pure (R)-4-(phenylsulfonyl)-2-butanol was obtained by hydrogen peroxide oxidation.

本文言語English
ページ(範囲)233-234
ページ数2
ジャーナルChemistry Letters
3
DOI
出版ステータスPublished - 1996 1月 1

ASJC Scopus subject areas

  • 化学 (全般)

フィンガープリント

「Biocatalytic preparation of (R)-(-)-4-(phenylthio)-2-butanol and (R)-(-)-4-(Phenylsulfonyl)-2-butanol by the sequential use of Pichia farinosa and Rhodococcus rhodochrous」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル