Biocatalytic strategies for the asymmetric synthesis of profens – recent trends and developments

Robert Kourist, Pablo Domínguez de María, Kenji Miyamoto

研究成果: Article査読

52 被引用数 (Scopus)

抄録

The profen family belongs to the most important non-steroidal anti-inflammatory drugs (NSAIDs). A considerable number of biocatalytic processes for the synthesis of optically pure (S)-profens have been proposed. Despite of the excellent enantioselectivity and the large advantages that enzyme catalysis offers in terms of sustainability, biocatalytic processes have failed so far to meet the technical and economic challenges of commercialization. This critical review outlines recent trends and developments of novel applications that appear very promising in terms of enantioselectivity, efficiency, sustainability and yield. Special emphasis is placed on the contribution of protein engineering in overcoming the limitations of these enzymes for technical applications, and thus providing promising biocatalysts for the preparation of pharmaceutical products. The natural catalytic diversity, assisted by modern methods of protein engineering, provides novel concepts and leads for the environmentally friendly synthesis of pharmacologically important drugs. Considerable progress can be expected in the coming decades. Furthermore, aspects regarding ecological footprints and the impact of each biocatalytic route are critically addressed, considering aspects like the type of solvent, waste produced, availability of substrate, etc. When possible, suggestions for combining efficiency with more sustainable synthetic approaches are also given.

本文言語English
ページ(範囲)2607-2618
ページ数12
ジャーナルGreen Chemistry
13
10
DOI
出版ステータスPublished - 2011 1 10

ASJC Scopus subject areas

  • 環境化学
  • 汚染

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