Biocompatibility of hydroxyapatite films formed on Ti metal by a simple urea and urease treatment

J. Nozaki, M. Aizawa, H. Uchida, K. Itatani, H. Suemasu, A. Nozue, I. Okada, M. Matsumoto, H. Matsumoto, Y. Toyama

研究成果: Conference article査読

3 被引用数 (Scopus)


HAp films with good adhesive property were formed by a simple surface treatment utilizing an enzyme reaction of urea with urease. The resulting coating layer consisted of carbonate-containing HAp with poor crystallinity. The in vitro evaluation using osteoblastic cells showed that HAp-coated Ti substrate had a good cellular response, such as cell proliferation and differentiation into osteoblast. From the results of in vivo evaluation using rabbit models, the HAp-coated Ti substrate directly bonded to bones to form large amount of new bone around implant. It has been found from both the in vitro and in vivo evaluations that the present HAp-coated Ti substrate has excellent biocompatibility.

ジャーナルKey Engineering Materials
出版ステータスPublished - 2003
イベントProceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia
継続期間: 2002 12月 42002 12月 8

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学


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