Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Akimichi Shibata, Shuhei Yada, Mitsuhiro Terakawa

研究成果: Article査読

31 被引用数 (Scopus)

抄録

Biodegradation is a key property for biodegradable polymer-based tissue scaffolds because it can provide suitable space for cell growth as well as tailored sustainability depending on their role. Ultrashort pulsed lasers have been widely used for the precise processing of optically transparent materials, including biodegradable polymers. Here, we demonstrated the change in the biodegradation of a poly(lactic-co-glycolic acid) (PLGA) following irradiation with femtosecond laser pulses at different wavelengths. Microscopic observation as well as water absorption and mass change measurement revealed that the biodegradation of the PLGA varied significantly depending on the laser wavelength. There was a significant acceleration of the degradation rate upon 400 nm-laser irradiation, whereas 800 nm-laser irradiation did not induce a comparable degree of change. The X-ray photoelectron spectroscopy analysis indicated that laser pulses at the shorter wavelength dissociated the chemical bonds effectively, resulting in a higher degradation rate at an early stage of degradation.

本文言語English
論文番号27884
ジャーナルScientific reports
6
DOI
出版ステータスPublished - 2016 6 15

ASJC Scopus subject areas

  • 一般

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